Difference between sedating and non sedating antihistamines
A short cut review was carried out to establish whether non-sedating antihistamines reduced symptom severity or duration in the common cold.
156 papers were found using the reported searches, of which 4 presented the best evidence to answer the clinical question.
This includes conditions such as: Other conditions such as hyper-reactive (vasomotor) rhinitis and pruritus of any cause are commonly treated with antihistamines, although there is little evidence that histamine plays a contributory role.
There is little evidence that antihistamines used symptomatically to treat nonspecific itching have any effect greater than placebo.
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They are used primarily to treat disorders where abnormal or excessive histamine release by inflammatory cells is thought to underly illness.The question, is it necessary to spend the extra money?" These newer products, which include Allegra, Zyrtec, and Claritin, generally cost between 10 to 20 times as much as the older, "first-generation" products.The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated.It is concluded that there is no good evidence for the use of non-sedating antihistamines in the common cold.